ABSTRACT
Background: COVID-19 vaccines shows good efficacy in the course of COVID19 pandemic, but some people still become infected with SARS-CoV-2 even after vaccination. The present study is to identify the disease progression in SARS -CoV2 infection among post-vaccinated patients with first and second dose of vaccinations. Methods: This is a retrospective observational study of 108 vaccinated, hospitalized confirmed covid-19 patients at tertiary care hospital from July,2021 to August,2021. Patients data in terms of vaccine status, type of vaccine, duration from last dose, inflammatory markers , comorbidities, severity of illness are collected and analyzed. Result: Total 500 patients of which 21% (108) got vaccinated. 68% (74) patients received single dose of vaccination and remaining 32% (34) patients completed two doses. 74% (80) patients were diagnosed through RAT/RTPCR and 26% (28) patients based on HRCT-Chest. 59% (64) patients had co-morbidities of which 65% (42) patients taken single dose and 35% (22) patients completed two doses. 35% (38) patients required O2 support, out of which 73% (28) has taken single dose and 27% (10) completed two doses. Average duration of hospital stay is 7 days in non oxygen dependent patients, 13 days in O2 / NIV support patients. Total 8%(8)deaths were reported of which 50%(4) received single dose of vaccination and 50%(4)completed two doses. Conclusion: In vaccinated patients disease severity is mild. In patients with co-morbidities who received single dose, requirement of O2/NIV was more when compared to patients who received both doses. Mortality is seen in patients with co-morbidities, even with complete vaccination.